Therapeutic management of breast cancer include frequently among other therapies tamoxifen (an antiestrogen drug in hormonal therapy) and chemotherapy’s drugs such as doxorubicin (a cytotoxic antibiotic) and paclitaxel (an antimicrotubule agent), both widely used for estrogen-dependent breast cancer and metastatic breast cancer. The important risk factors of mammary cancer include an estrogen exposure, age, mutations in tumor suppressor genes (BRCA1 and BRCA2), obesity, and environmental pollutants (polycyclic aromatic hydrocarbons). In Cameroon, breast cancer is the first cancer of women with 2625 news cases each year. According to the same authors, in 2016, breast cancer alone is expected to account for 29% of all new cancers diagnosed in women. The three most commonly diagnosed cancers in women include breast, lung and bronchus, and colorectal cancer. In the year 2015, global cancer cases were estimated to 15.2 million with 8.9 million of deaths. IntroductionĬancer is a major public health problem worldwide. Taken altogether, these results suggest that the hydroethanolic extract of Acacia seyal might contain phytoconstituents endowed with antitumoral properties, which could protect against the breast cancer induced in rats. It protected rats against DMBA-induced breast hyperplasia, with an optimal effect at the dose of 300 mg/kg. Acacia seyal extract significantly ( ) and in the dose-dependent manner reduced tumor incidence (3 rats out of 12 at the dose of 300 mg/kg), burden, and mass. In vivo, no tumors were detected in rats from the control group, while 11 rats out of 12 (91.66%) developed mammary tumors in the DMBA-exposed group receiving only the vehicle. The Acacia seyal extract exhibited CC 50 of 100 in MCF-7 cells after 24 h. Incidence, burden, volume, and histological analysis of mammary tumors were measured. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model.

Further, the protective effect of the hydroethanolic extract of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. seyal hydroethanolic extract on breast cancer. The present study was designed to evaluate the in vitro and in vivo antitumor effects of A.

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